TY  - JOUR
AU  - Chakraborty, Aparajita
AU  - De, Priyanka
AU  - Saha, Sudipa
T1  - Elucidating the mechanism of anti-apoptotic activity of α-crystallin and its therapeutic potential
JO  - Journal of Stress Physiology & Biochemistry
Y1  - 2025/march
VL  - 21
IS  - 1
SP  - 182
EP  - 189
UR  - http://www.jspb.ru/issues/2025/N1/JSPB_2025_1_182-189.pdf
KW  - α- Crystallin
KW  - antiapoptotic mechanism
KW  - pro-apoptotic members
KW  - Bax
KW  - Bcl-2
KW  - Caspase-3
KW  - Caspase-9
KW  - retinal degenerations
KW  - IKKβ
KW  - NF-ĸB
KW  - therapeutic purposes
U1  - 1997-0838
N2  - α- Crystallins are the structural proteins of the eye lens which possess anti-apoptotic activity. Both αA- and αB- crystallins are distinct antiapoptotic regulators which can interact with Bax and Bcl-XS, proapoptotic members of the Bcl-2 family in order to sequester their translocation into the mitochondria. Thus they may interfere with the mitochondrial apoptotic pathway which triggers Bax pro-apoptotic activity and the downstream activation of effector caspases such as Caspase-9 and Caspase-3. The differential regulation of α- crystallins has been observed in several ocular diseases such as age-related macular degeneration and many others. Crystallins interact with pro-apoptotic Bax and displayed cytoprotection against Bax-triggered apoptosis. αA-crystallin was found to inhibit chemical-induced apoptosis by inhibiting the activation of caspase-3 and caspase-9. Its antiapoptotic activity was found to be directly related to its chaperone activity. On the other hand, αB- crystallin associated with IKK-β activates its kinase activity which in turn, leads to the activation of NF- ĸB; this activation protects myoblasts from tumor necrosis factor-α (TNF-α) - induced cytotoxicity by enhancing the expression of Bcl-2, an anti-apoptotic protein. The anti- apoptotic mechanisms may be exploited for therapeutic purposes in near future.
ER  -