| ORIGINAL ARTICLE |
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Background and Aim: Laboratory assessment of sialic acid as a
marker of microvascular complications can be a diagnostic tool for
diabetes mellitus. Microalbumin is an established predictor of diabetic
nephropathy. The study was undertaken to evaluate serum sialic acid and
microalbumin levels and to correlate it with glycemic control in
diabetic nephropathy patients.
Material and Methods:
Clinically diagnosed diabetic nephropathy patientsvisiting the medicine
OPD (outdoor patient department) and NCD (Non-Communicable Disease)
were selected for the study. This study included 75 subjectswith
diabetes types 2 of which 44 were males and 31were females. Control
includes a total of 75 out of which 49 Males and 26 females. Blood
samples were analysed for the glucose, C-reactive protein, and sialic
acid. Urine sample was analyzed for microalbumin and sialic acid.
Results: The mean value of FBS
was 161±53.2 mg/dl which was significantlyhigher than controls
81±5.2. The Sialic acid in subjects was 105±21 mg/dl which is
higher than controls 51±6 mg/dl. The urine microalbumin level was found
to be 96.5±17.2 in subjects, whereas 6.4±1.6 mg/dl was in controls.
Serum Creatinine level in subjects was 8.75±2.05 mg/dl which was higher
than subjects 0.8±0.3mg/dl. Serum Urea in diabetic nephropathy subjects
was 93.5±15.4 mg/dl, which is positively higher than controls 30.8±7.1
mg/dl.
Conclusion: Urine microalbumin
is established as a potential marker for diabetic nephropathy. The
correlation of serum sialic acid, urine microalbumin and serum
creatinine proposed serum sialic acid as an accessory diagnostic marker
for diabetic nephropathy. Estimation of sialic acid before microalbumin
in diabetic patients helps assess glycemic control and identify the
risk for nephropathy and other secondary complications of diabetes
mellitus, which are the main causes of mortality and morbidity among
type-2 diabetes mellitus patients.
Key words: Diabetes Mellitus, Sialic Acid, Serum Creatinine, Urine Microalbumin
