ORIGINAL ARTICLE |
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Objective:
The present study is aimed to evaluate the curative effect of herbal
ointment containing Peristrophe paniculata Forssk. against incision
wound.
Methods: Animals weighing 150
-200g were divided into five groups each comprising of six rats: Group
I served normal control, Group II served as incision wounded control
and Group III, IV served as incision wounded animals were treated with
10% and 20% of herbal ointment (HO) containing Peristrophe paniculata
Forssk. applied topically for 14 days respectively and group V served
as incision wounded animals treated with reference ointment
soframycin. The healing of wound was assessed by
breaking strength, level of hydroxyproline, hexosamine, tissue
and serum protein, ascorbic acid, Deoxyribonucleic Acid (DNA),
Ribonucleic Acid (RNA), Superoxide Dismutase (SOD), Lipid Peroxidation
(LPO).
Results: The topical
application of herbal ointment treated groups showed increase in
hydroxyproline, hexosamine, protein, breaking strength, DNA, RNA and
SOD, Ascorbic acid and significant decrease in the LPO.
Conclusion: The results
concluded that the Peristrophe paniculata Forssk. has the efficacy in
the management of wound healing. Further in-depth studies will be
carried out by the isolation of active compounds for drug discovery.
Key words: Wound, Antioxidants, Herbal Ointments, Peristrophe paniculata Forssk