ORIGINAL ARTICLE

Wound Healing Efficacy of Herbal Ointment Containing  Peristrophe paniculata Forssk. on Incision Wounded  Animals

Objective: The present study is aimed to evaluate the curative effect of herbal  ointment containing Peristrophe paniculata Forssk. against incision wound.
Methods:  Animals weighing 150 -200g were divided into five groups each comprising of six  rats: Group I served normal control, Group II served as incision wounded control and  Group III, IV served as incision wounded animals were treated with 10% and 20% of  herbal ointment (HO) containing Peristrophe paniculata Forssk. applied topically for  14 days respectively and group V served as incision wounded animals treated with  reference ointment soframycin. The healing of wound was assessed by breaking  strength, level of hydroxyproline, hexosamine, tissue and serum protein, ascorbic acid,  Deoxyribonucleic Acid (DNA), Ribonucleic Acid (RNA), Superoxide Dismutase  (SOD), Lipid Peroxidation (LPO).
Results: The topical application of herbal ointment  treated groups showed increase in hydroxyproline, hexosamine, protein, breaking  strength, DNA, RNA and SOD, Ascorbic acid and significant decrease in the LPO. 
Conclusion: The results concluded that the Peristrophe paniculata Forssk. has the  efficacy in the management of wound healing. Further in-depth studies will be carried  out by the isolation of active compounds for drug discovery.