TY  - JOUR
AU  - Abdulkadir, Teslim S.
AU  - Ayo, Joseph O.
AU  - Isa, Ahmed Sherif
AU  - Dawud, Fatima A.
AU  - Dimka-Bashok, Lengnen
AU  - Jafar, Fatima Y.
T1  - Taurine and/or Camel Milk Mitigates Haemolysis and Malondialdehyde Concentration in Alzheimer Rats
JO  - Journal of Stress Physiology & Biochemistry
Y1  - 2023/december
VL  - 19
IS  - 4
SP  - 5
EP  - 14
UR  - http://www.jspb.ru/issues/2023/N4/JSPB_2023_4_05-14.pdf
KW  - Aluminum chloride
KW  - camel milk
KW  - malondialdehyde
KW  - taurine
KW  - oxidative stress
U1  - 1997-0838
N2  - Alzheimer’s disease (AD) is a devastating neurodegenerative disease, affecting all age groups. Malondialdehyde (MDA) concentration and haemolysis are important oxidative stress biomarkers, implicated in the pathogenesis of AD. The study aimed to evaluate taurine, camel milk (CM) and their combined effects on MDA concentration and haemolysis in AD rats. The animal groupings were; Normal saline (0.2 mL/mg bw); AlCl3 (100 mg/kg); CM (33 mL/kg); Taurine (50 mg/kg); AlCl3 (100 mg/kg) + CM (33 mL/kg); AlCl3 (100 mg/kg) + Taurine (50 mg/kg) and AlCl3 (100 mg/kg) + CM (33 mL/kg) + Taurine (50 mg/kg). Concentration of MDA and percentage haemolysis were determined for all groups. At 0.5% NaCl, haemolysis in AD rats (64.00 ± 1.27 %) was higher (p < 0.05) than in AD + CM (51.50 ± 2.96 %) and AD + CM + Taurine (52.00 ± 1.53%) rats. MDA concentration was lowered (p < 0.05) in taurine-treated rats than controls, but it increased with haemolysis in AD rats compared to other groups. Taurine and/or CM exhibited antioxidant activity by decreasing haemolysis and MDA concentration in AD groups, and may be beneficial in mitigating AD-induced oxidative stress changes.
ER  -