Impact of Antabuse Treatment on Dyslipidemia and Oxidative Stress Levels in Chronic Alcoholism

Shanmugapriya, V.; Karthikeyan, D.; Ravish, H.; Srinivas, H.

Journal of Stress Physiology & Biochemistry, Vol. 16 No. 4 2020, pp. 113-118 ISSN 1997-0838
Original Text Copyright (cc) 2020 by Shanmugapriya, Karthikeyan, Ravish and Srinivas

ORIGINAL ARTICLE

Impact of Antabuse Treatment on Dyslipidemia and Oxidative Stress Levels in Chronic Alcoholism

Shanmugapriya V.¹, Karthikeyan D.², Ravish H.³, Srinivas H.⁴

¹ Department of Biochemistry, Vinayaka Mission’s Medical College & Hospital, (VMRF-DU ) Karaikal, Puducherry-609609
² Department of Microbiology, Vinayaka Mission Medical College & Hospital (VMRF-DU), Karaikal, Puducherry, 609609
³ Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Administrative Block (Adjacent to the Director's office), Hosur Road/ Marigowda Road, Lakkasandra, Wilson Garden, Bangalore-560029, Karanataka, India.
⁴ Department of Biochemistry, Bowring and Lady Curzon Medical College and Research Institute, Bangalore 560 001, Karanataka, India.

*E-Mail: drsrinibiochem@gmail.com, srinivas.h81@gov.in

Received July 15, 2020

Background: Chronic alcoholics are known to have dyslipidemia, which can aggravate organ dysfunction along with increased oxidative stress due to alcohol metabolism. We are studying the impact of Antabuse treatment in reversing the damages caused by chronic alcoholism at metabolite level.
Results: This is hospital based cross sectional case control study, with 34 chronic alcoholic patients and 20 Antabuse treated patient for alcoholism. The mean plasma MDA (oxidative stress marker) level among the chronic alcoholics was 12.3 ± 4.3 µmol/L and in Antabuse treated group was 2.8 ± 0.3 µmol/L. Chronic alcoholic group had significantly elevated lipid profile then Antabuse treated group suggesting dyslipidemia in alcoholic group in our study population.
Discussion: We observed positive correlation between oxidative stress marker and Lipid profile. Dyslipidemia and oxidative stress levels were significantly lower in Antabuse treated patients suggesting early treatment of such addicts and complete abstinence from consumption showed reversal of the metabolic derangement caused by chronic alcoholism.

Key words: Alcoholism, Oxidative Stress, Dyslipidemia, Malondialdehyde, Disulfiram