ORIGINAL ARTICLE

Uric Acid Level in Advanced Age of Patients with Rheumatoid Arthritis

Rheumatoid arthritis is a long-term autoimmune disorder causes chronic inflammation of the joints. The pathogenesis of this disease is linked predominantly with the formation of free radicals at the site of inflammation. Uric Acid is an endogenous aqueous antioxidant and considerably higher than the ascorbate level, making it one of the major antioxidants to scavenges the singlet oxygen and radicals in the blood stream. The present study was aimed to estimate the Uric acid levels along with C-reactive protein, Erythrocyte sedimentation rate, Malondialdehyde level and calcium in patients with rheumatoid arthritis and compared with healthy individual. Results showed that with the age matched control between 30-40 and 40-50 changes in the Uric acid level was not signification but showed significant elevation in C-reactive protein, Erythrocyte sedimentation rate and Malondialdehyde level rate observed in the studied age group. The present study evidently concludes that advancing age decrease in the Uric acid level was observed both genders may insult in oxidative stress induced damage.