Journal of Stress Physiology &
Biochemistry, Vol. 9 No. 4
2013, pp. 180-186 ISSN 1997-0838
Original Text Copyright (cc) 2013 by Zhu, Di, Jia, Zhang, Wang
ORIGINAL ARTICLE
Data source : Google Scholar
QueryDate : 2016-12-24
Cites : 0
Comparison of Nonshivering
Thermogenesis Induced by Norepinephrine Stress in Tree Shrews
Wan-long Zhu 1#, Di
Zhang 1, Jia Zheng 1#, Lin ZHang 1,
Jin-hu Liu 2, Jin Cheng 2, Zheng-kun Wang 1*
1 School of life Science of
Yunnan Normal University, Kunming, 650500, China 2 Pingliang medical college, PingLiang, 744000, China
# Zhu WL and Zheng J contributed equally to this work
*E-Mail: zwl_8307@163.com
Received July 1, 2013
Nonshivering thermogenesis (NST)is
an important thermogenic mechanism for small mammals.
Quantitative measurement of NST is
usually stimulated by injection of
norepinephrine. The injection dosage of norepinephrine (NE) is
critical for eliciting the maximum NST. Three empirical equations of NE
dosages were often referenced in previous studies: (1) NE (mg / kg)=
2.53W-0.4; (2) NE(mg/kg) = 3.3W-0.458 and (3)
NE(mg/kg)= 6.6W-0.458. In the present study , we used tree
shrews (Tupaia belangeri) as
experiment subjects to test the effects of the three dosages of NE on
NST. Results showed that all the three dosages of NE could induce the
maximum NST for T. belangeri.
No significant differences were found in NST among groups and the NST
was respectively 2.63±0.12 (formula 1), 2.66±0. 11 (formula 2) and
2.78±0.15 (formula 3). However, when injected with NE dosage from
formula 3, the increase of body temperatures was significantly higher
than the other two NE dosages (increased 1.5±0. 1 oC (formula 3), 0.8±0. 2 oC
(formula 2), and 0.6±0. 1 oC (formula 1),
respectively). In order to prevent
the death because of hyperthermia,
formula 1 or 2 is recommended to be used.
