Journal of Stress Physiology &
Biochemistry, Vol. 9 No. 1
2013, pp. 136-147 ISSN 1997-0838
Original Text Copyright (cc) 2013 by Shabir, Sarumathi, Anbu and
Saravanan
ORIGINAL
ARTICLE
Data source : Google Scholar
QueryDate : 2016-12-24
Cites : 8
Gallic Acid Protects Against
Immobilization Stress-Induced Changes In Wistar Rats
Shabir Ahmad Rather1, A.
Sarumathi1, S. Anbu1, N. Saravanan2* 1 Faculty of Science, Department of Biochemistry and
Biotechnology, Annamalai University, Annamalinagar–608002, Tamil Nadu,
India 2 Lecturer in Biochemistry, Rani Meyyammai College of
Nursing, Faculty of Medicine, Annamalai University,
Annamalinagar–608002, Tamil Nadu, India
Tel.: (91) 4144-237225 Fax: (91) 4144-237225
*E-Mail: saravanan_74@rediffmail.com
Received October 20, 2012
Background: Stress triggers a wide
range of body changes. Herbal medicines are rich in non specific
antistress agents. Purpose: The present study was
carried out to evaluate the antistress effect of gallic acid (GA), a
naturally occurring plant phenol, on immobilization induced-stress in
male albino Wistar rats. Methods: The
immobilization stress was induced in rats by putting the rats in 20 cm
× 7 cm plastic tubes for 2 h/day for 21 days. Rats were post orally
treated with GA at a dose of 10 mg/kg body weight via
intragastric intubations. Results:Treatment with GA
significantly increased the food intake, body weight, organ weight
(spleen, testis and brain) and the significant reduction was found in
weight of liver, kidney, heart and adrenal glands, which was altered in
stressed rats. GA also significantly reduced the elevated levels of
plasma glucose, plasma and tissue cholesterol (CHL), triglycerides
(TG), Low Density Lipid (LDL), Very Low Density Lipid (VLDL) and also
significantly increased the level of High Density Lipid (HDL). A
significant decrease in hematological parameters like RBC count, total
and differential WBC count was also found which were increased in
immobilization stress. Conclusion: GA prevented the
stress-induced physiological, biochemical and hematological changes,
indicating the preventive effect against stress.
