QueryDate : 2016-12-24
Cites : 1
| ORIGINAL
ARTICLE |
| | | Data source : Google Scholar QueryDate : 2016-12-24 Cites : 1 |
Background: Despite
significant advances in understanding and management of
neuropsychiatric disorders during past few decades, anxiety and
depression, still remains the leading cause of deaths, primarily for
want of effective and safe treatment of these ailments. Approximately,
two third of the anxious or depressed patients respond to the currently
available treatment but the magnitude of improvement is still
disappointing
Purpose of Study: The aim of
the present study was to investigate the antianxiety activity of
Gelsemium sempervirens (Linn.) Ait. Various doses (50,100, 150,
200mg/kg) of plant extracts viz., of petroleum ether, chloroform,
methanol and water were administered orally to Swiss Albino Mice before
evaluating their behavioural pattern. Diazepam (2.5 mg/kg) was used as
standard drug.
Result: The methanol extract of
G. sempervirens (150 mg/kg) increased the mean time spent, mean number
of arms entries in the open arms of elevated plus maze (EPM) and
decreased the mean time spent in the closed arms. The locomotor
activity of methanol extract was not affected to the same extent as
observed for diazepam.
Conclusion: The results
suggested that methanol extract of G. sempervirens possess anxiolytic
effects with no sedative activity when compared to diazepam.
