Journal of Stress Physiology & Biochemistry, Vol. 7, No. 2,
2011, pp. 164- 174. ISSN 1997-0838
Original Text Copyright (cc) 2011 by Nabavizadeh, Vahedian, Sahraei,
Adeli, and Salimi
ORIGINAL
ARTICLE
Data source : Google Scholar
QueryDate : 2016-12-24
Cites : 2
PHYSICAL AND PSYCHOLOGICAL STRESS HAVE SIMILAR
EFFECTS ON GASTRIC ACID AND PEPSIN SECRETIONS IN RAT
Nabavizadeh1 Fatemeh,
Mohammad Vahedian2, Hedayat Sahraei3, Soheila
Adeli1, and Ehsan Salimi1 1 Department of physiology, Tehran University of Medical
Sciences, Tehran, Iran 2 Department of Orthopaedy, Tehran University of Medical
Sciences, Tehran, Iran 3 Applied Neuroscience Research Center, Baqyiatallah (a.s)
University of Medical Sciences, Tehran, Iran
E-mail: Nabavizadeh2000@yahoo.com
Phone: 00989133410451
Fax: 00982166419484
Received April 23, 2011
Stress is one of the most important health and social
problems. Previous studies have demonstrated stress influence on the
clinical course of a number of gastrointestinal diseases, but its
physical and psychological effects on gastric acid and pepsin
secretions are largely unknown. 48 male wistar rats weighing 200-250 gr
were used in this study. Animals were divided into 6 groups (n=8);
Control, Physical stress, Psychological stress, L-NAME+ Physical stress
and L-NAME+ Psychological stress groups. In this study, electrical
shock generated in a communication box was used as physical shock and
the emotional stress was as psychological stress.
Gastric juice was collected by washout technique. Acid output was also
measured by digital titrator. Gastric pepsin and nitric oxide (NO)
metabolites were quantified using Anson and Griess micro assay methods
respectively.
Basal and stimulated gastric acid and pepsin in physical and
psychological stress groups were significantly more than others. NO
metabolites level of gastric tissue in physical and psychological
stress groups (286.9 ± 5.8, 287.7 ± 5.7 μmol/gr weight wet tissue,
respectively) were significantly more than other groups. But no
significant differences among basal and stimulated gastric acid, pepsin
and NO metabolites level were seen in physical and psychological stress
groups.
Key
words: Physical, Psychological, Stress, Gastric acid, Pepsin, Rat
