Journal of Stress Physiology & Biochemistry, Vol. 7, No. 2,
2011, pp. 139- 147. ISSN 1997-0838
Original Text Copyright (cc) 2011 by Devaki, Nirupama,
Yajurvedi
ORIGINAL
ARTICLE
Data source : Google Scholar
QueryDate : 2016-12-24
Cites : 4
REDUCED ANTIOXIDANT STATUS FOR PROLONGED PERIOD DUE
TO REPEATED STRESS EXPOSURE IN RAT
Devaki, M*., Nirupama, R. and
Yajurvedi, H.N.
Research Scholar, Department of Zoology, University of Mysore,
Manasagangotri, Mysore-570 006, India
E-mail: devaki.chm@gmail.com
Phone: +91-0821-2419778
Fax: +91-0821-2421263(pp)
Received April 16, 2011
Abstract – The objective of the study was to find out whether or not
exposure to a stressor after an initial stressful experience
augments stress response. Antioxidant status was determined by
measuring changes in the activities of the hepatic free radical
scavenging enzymes viz, superoxide dismutase (SOD),
glutathione-S-transferase (GST), glucose-6-phosphate-dehydrogenase
(G6PDH) and catalase (CAT) and levels of hepatic malondialdehyde (MDA)
following exposure to 1 h restraint (RS) and after a gap of 4 h to
forced swimming exercise (FS) in rats. The activities of hepatic CAT,
SOD, G6PDH and GST were significantly reduced 2 h after RS
compared to controls and 4 h after FS the activities of CAT and
G6PDH remained at lower levels i.e. they were similar to those found
after RS , whereas SOD and GST showed further significant
decrease compared to those found after RS. On the other hand the MDA
levels, indicative of lipid peroxidation were significantly increased
after RS and showed further significant increase after FS. The results
reveal that after initial stressful experience, the stress
response is augmented due to exposure to another stressor whereas the
system does not get habituated to stress exposure.
