Journal of Stress Physiology & Biochemistry, Vol. 6 No. 4
2010, pp. 28-41 ISSN 1997-0838
Original Text Copyright (cc) 2010 by OmAli Y. El-Khawaga; Abou-Seif M.A;
El-Waseef A. and Negm A.A
ORIGINAL
ARTICLE
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QueryDate : 2016-12-24
Cites : 10
Hypoglycemic, Hypolipidemic and Antioxidant Activities of
Cleome droserifolia in Streptozotocin-Diabetic Rats
OmAli Y. El-Khawaga1,2*, Abou-Seif M.A1.,
El-Waseef A. 1 and Negm A.A1.
1Biochemistry Department,
Faculty of Science, Mansoura University, Mansoura, Egypt.
*Corresponding Author: dr_elkhawaga@yahoo.com 2Current address: Faculty of Community, King Khalid
University, Rejal Almaa 61956, P. Box. 76, Kingdom of Saudi Arabia, Fax: 0096672580857
Received September 28, 2010
Background:
Diabetes mellitus (DM) is characterized by absolute or relative
deficiencies in insulin secretion and/or insulin action associated with
chronic hypoglycemia clinical research has confirmed the efficacy of
several plant extracts in the amelioration of diabetic disorders. Aim
of the work hypolipidemic and antioxidant activities of the aqueous
extract of Cleome droseriloia
was investigated in streptozotocin
(STZ)-induced diabetic rats.
Methods and Results: A single
dose of STZ (60mg/Kg body weight) produced a decrease in hepatic
glycogen and GSH contents, hepatic glucose-6-phosphate dehydrogenase,
superoxide dismutase, activities and HDL- cholesterol, whereas, hepatic
glucose-6-phosphatase activity and level of MDA, cholesterol,
triglyceride, LDL-cholesterol and VLDL-cholesterol were increased. An
aqueous extract of Cleome droseriloia
(500, 750 and 1000mg/Kg) or Gliclazide (100mg/Kg) was administered
orally once daily for two weeks to STZ-induced
diabetic rats ameliorated hyperglycemia, improved lipid profile,
amelioration of antioxidants and restored the metabolic enzymes of
glucose to the normal value in the liver of STZ-treated rats. In
addition, the administration of Cleome
droserifolia induced the
secretion of insulin from pancreatic rats. Furthermore, the
hypoglycemic efficacy of one dose of aqueous extract Cleome
droserifolia has extended to 12 hours. The effects produced by Cleome droserifolia extract were
found to be comparable with that of gliclazide.
Conclusion: The present results
suggested that Cleome droserifolia
could be used as antidiabetic
complement of diabetes mellitus. This may be related to its
insulin-induction action.
