The L.N. Gumilev Eurasian national
university, 01000, Astana, Munaitpasov str, 5 Kazakhstan
The Medical university of Astana, 01000, Astana, Beybitshilyk str, 49
Kazakhstan Tel: (717-2) 53-95-37 E-mail: mashetseva@gmail.com Received October 27, 2009
Phospholipids (PL) are universal components
of cell membranes. They can be used as objective indices of normal or
pathological organism states. The changing nature of the quantitative
composition of PL is indicating the intensity of oxidative stress as
well as the efficiency of exogenous plant antioxidants.
The PL dynamics of the ischemia in experimental rat’s was investigated.
The change of that parameter using the preventive injection of some
vegetation organs of Kazakhstan birch extract.
The extracts of the birch vegetation organs in experimental group were
dosed in the amount of 5 mg/kg. In order to investigate PL dynamics,
the tissues of brain, liver, and kidney have been studied.
In order to estimate the PL change range in rat homogenate, the
correlation between neutral and acid PL. Despite the fact that the
amount of acid PL in the bio-membranes is less than the neutral ones,
the latter regulate membrane functions in a higher degree.
It has been found that the rats which had experienced ischemia have a
decreased amount of acid PL in the homogenates. Preventive injection of
birch extracts brings about normalization of PL level. This fact points
out a possibility of applying extracts of Betula Pendula Roth in order
to regulate the PL level of experimental rats as well as an estimation
of the antioxidant effect of exogenous substances.
key words: oxidation stress, Lipid
peroxidation, antioxidants, Betula
pendula Roth., Populus balsamifera L.
