Journal of Stress Physiology & Biochemistry, Vol. 4, No. 2,
2008, pp. 14- 29. ISSN 1997-0838
Original Text Copyright (cc) 2008 by Abdel-Sater
ORIGINAL
ARTICLE
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QueryDate : 2016-12-24
Cites : 2
EFFECTS OF EXERCISE ON CARDIOVASCULAR DYSFUNCTIONS
INDUCED BY CIGARETTE SMOKING
Khaled A. Abdel-Sater
Department of Physiology, Faculty of
Medicine, Al-Azhar University- Assiut Branch- Assiut, Egypt e-mail: khaled_71111@yahoo.com
Received April 26, 2008
Abstract – Smoking is known to adversely affect many organs and
systems in human, where the cardiovascular system is one of the
important targets. However, the exact mechanisms by which cigarette
smoke alters myocardial and endothelial cells function and induces
cardiovascular pathology are not clear. There are no reports
especially with nitric oxide (NO•), uric acid and hemodynamics after
acute exercise in smokers up to date. This study is designed to
investigate the role of oxidative stress, NO• and uric acid in the
pathophysiologic mechanisms of smoking- induced cardiovascular diseases.
40 apparently healthy subjects were studied. Depending on their
previous physical conditioning status subjects were divided into equal
four groups (n=10), physically active nonsmokers, physically active
smokers, sedentary nonsmokers and sedentary smokers. Exercise tolerance
was evaluated for each subject by using a running race (3 kilometers)
after a worming up period of 5 minutes.
The obtained data revealed that regular exercise significantly
decreased the plasma malonaldehyde, total cholesterol, LDL and uric
acid levels below sedentary levels. Pre and post race plasma level of
malonaldehyde and uric acid levels were significantly increased, while,
plasma glutathione and NO• were decreased in sedentary smokers than the
sedentary non smokers, physically active smokers and physically active
non smokers.
These findings point to the role of NO•, uric acid and lipid peroxide
in the pathophysiologic mechanisms of smoking induced cardiovascular
diseases. Sedentary smokers may be at an even greater risk of oxidative
stress-related cardiovascular diseases. Finally, every body should
include in a regular exercise.
